Web15 feb. 2013 · The Journal of Biological Chemistry Background: The tumor suppressor gene HIC1 (hypermethylated in cancer 1) encodes a transcriptional repressor SUMOylated at Lys-314. Results: DNA damage favors SUMOylation of HIC1 and its interaction with MTA1 to regulate the DNA repair process. Web13 apr. 2012 · Introduction. HIC1 (Hypermethylated in Cancer 1) was originally identified as a new candidate tumor suppressor gene located at 17p13.3 region telomeric to TP53 [].It is more clear that epigenetic changes, located in the chromosomal region 17p13.3, often show loss of heterozygosity or DNA hypermethylation that resides in CpG islands in area …
Cancers Free Full-Text SOX1 Functions as a Tumor Suppressor …
WebKaiso causes transcriptional repression of several well-known tumor suppressor genes like Retinoblastoma (Rb), Hypermethylated In Cancer 1 (HIC1) and Cyclin-Dependent … Web25 jan. 2024 · Hypermethylated-in-Cancer 1 ( Hic1) is a tumor suppressor gene frequently inactivated by epigenetic silencing and loss-of-heterozygosity in a broad range of … pete scazzero the wall
DNA Double-strand Breaks Lead to Activation of Hypermethylated …
Web23 mrt. 2024 · GSN had varying impacts on the prognosis of various tumor types. However, all had moderate to high diagnostic efficiency, and serum GSN had good diagnostic value in breast cancer patients (AUC = 0.947). Moreover, GSN was a distinguishing prognosis factor for some specific cancer types. WebCpG island hypermethylation is a phenomenon that is important for the regulation of gene expression in cancer cells, as an epigenetic control aberration responsible for gene … Web25 jul. 2024 · Hypermethylated in Cancer 1 (HIC1) is an established tumor suppressor, which is frequently inactivated in various cancers. In colorectal carcinoma (CRC), silencing of HIC1 has been recognized as one of the important events in malignant tumor progression. Strikingly, CRC patients with high HIC1 expression have a worse prognosis than patients … pete scarborough obituary